Unanchored ubiquitin chains
Web29 Jun 2012 · Unanchored ubiquitin chains are thought to be rare in living cells. To determine whether MDA5 binds to endogenous, unanchored, K63-linked polyubiquitin chains in cells, Jiang et al. (2012) isolated polyubiquitin chains that copurify with overexpressed MDA5 (N) in mammalian cell extracts. Web12 Oct 2024 · Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Bin Song, Yun Chen, Xin Liu, Fei Yuan, ... Jie Zheng. Pages 2218-2230.e5 View PDF. Article preview.
Unanchored ubiquitin chains
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Web7 May 2024 · Unanchored ubiquitin chains are also found inside the IAV virions. Upon entry, these polyubiquitin chains interact with HDAC6-dependent aggresome degradation machinery. Via microtubule movement, RNA segments of IAV are transported towards the nucleus and released into the nuclear pore [ 61 ]. Web26 Oct 2024 · Unanchored ubiquitin chains may also associate with ubiquitin-binding proteins in a “reserve” pool for later use in any of the other suggested routes of …
Web6 Jul 2015 · MJ Lee, BH Lee, J Hanna, RW King, D Finley, Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics 10 ... R Hao, et al., Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell 51, 819–828 (2013). Crossref. PubMed. Google Scholar. 31. F … Web5 Aug 2024 · Similarly, some E2 enzymes can build a pre-formed ubiquitin chain on their own active sites cysteine, allowing them to generate unanchored ubiquitin chains, but it remains unclear if these can be transferred en bloc to substrates . While en bloc transfer of ubiquitin chains has so far only been associated with formation of homotypic chains, it ...
Web22 Jun 2024 · cells Article Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF- B SignalingJessica R. Blount 1, Kozeta … Web21 Mar 2024 · UBB (Ubiquitin B) is a Protein Coding gene. Diseases associated with UBB include Cleft Hard Palate and Submucosal Cleft Palate . Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and MyD88 dependent cascade initiated on endosome . An important paralog of this gene is UBC.
WebDepartment of Microbiology and Immunology RESEARCH ACTIVITIES: (2024-Present) Graduate student collaborator with Dr. Ricardo Rajsbaum PhD: NIH Grant: “Unanchored Polyubiquitin Chains and Innate ...
WebUnanchored polyubiquitin chains are endogenous non-substrate linked ubiquitin polymers which have emerging roles in the control of cellular physiology. We describe an affinity purification method based on an isolated ubiquitin-binding domain, the chase trumpet playerWeb16 May 2024 · Addition of long unanchored K48-linked ubiquitin chains (UbL Ub), Ub-GFP, Ub3 Ub-GFP, or UbL Ub-UbL Ub-GFP did not alter the ATPase activity of p97 (Fig. S7A). … chase tryanWeb31 May 2024 · Based on these findings, we propose a model of unanchored chain management that comprises four potential routes (Fig. 7): the first is canonical, where … cuss in japaneseWeb19 Jun 2014 · TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKε for subsequent STAT1 … cuss in tagalogWebUbiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling ( By similarity ). By similarity GO annotations Expand table cuss interviews the strangerWebNational Center for Biotechnology Information chase trunks popWeb24 May 2024 · Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling Cells June 22, 2024 See publication. Expanding Role of Ubiquitin in Translational ... cus skeetchestn