WebToll-like receptors (TLRs) are key molecules of the innate immune systems, which detect conserved structures found in a broad range of pathogens and trigger innate immune responses. A subset of TLRs recognizes viral components and induces antiviral responses. Whereas TLR4 recognizes viral components at the cell surface, TLR3, TLR7, TLR8, and … WebMay 18, 2012 · TLR3 detects double-stranded RNA, which is produced during the replication cycle of most viruses, leading to activation of the transcription factors NF-κB and interferon regulatory factor (IRF) 3, and rapid and massive production of type I interferons (IFNs) and proinflammatory cytokines, such as IL-6 and IL-8 ( 3 ).
Cellular origins of dsRNA, their recognition and consequences
WebDec 30, 2013 · Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. ... function and regulation of the Toll/IL-1 receptor adaptor ... WebApr 29, 2008 · Identification of the TLR3-TICAM-1-mediated signaling cascades different from those of RIG-I/MDA5, ligand repertoire of TLR3, and dsRNA transport system provides new insights for understanding the TLR3 function in vivo, as well as for development of the TLR3-related vaccine adjuvant for tumor and/or infectious diseases. push image to local registry docker desktop
Toll-like receptors activation, signaling, and targeting: an …
WebDec 12, 2024 · TLR3 activation has been found to promote atherogenic inflammation, especially in mediating plaque instability (Ishibashi et al., 2013 ). In hypertension, TLR4 has been well-documented to mediate inflammation in vasculature (McCarthy et al., 2015 ). Sepsis Excessive TLR activation can lead to systemic inflammation, characterized as … WebThe identification of patients with mutations in key TLR3 signaling components has served as an experiment of nature that played a key role in elucidating the biological function of TLR3 in humans. Patients with mutations in genes encoding TLR3 have a selective immunodeficiency manifested by recurrent episodes of HSV-1 encephalitis [27,28] . WebTLR3 is expressed in various tissues and cells. In the human central nervous system, TLR3 is expressed constitutively in neurons, astrocytes, and microglia, suggesting a role in the … pushim soldier