Phloretin ic50 glut1
Webb輸送は,GLUT2阻 害剤phloretinに より阻害され る, 現在,SGLT1は 糖吸収における一種のセンサー として働くとする仮説が提唱されている.すなわち, 食事などにより消化管の管 …
Phloretin ic50 glut1
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Webb5 mars 2010 · Other hexoses transported by GLUT1 are galactose, mannose, and glucosamine . When expressed in S. cerevisae, rat GLUT1 showed a K m for D-glucose of … Webb7 dec. 2015 · Phloretin/Phlorizin, are very well know Glut1, SGLT1 and SGLT2 inhibitors. These are transporters responsible for transporting glucose into the the cells. For example, glucose symporter SGLT1, co-transports one glucose molecule into the cell for every two sodium ions it imports into the cell.
Webb16 dec. 2006 · IC 50 indicates flavonoid concentration at which sugar uptake was decreased by half compared with control without flavonoid. For experiments describing quercetin uptake by intestinal sugar transporters in injected oocytes, five or more oocytes were used for each experimental condition. Webb3 juni 2024 · The 2-deoxyglucose colorimetric assay showed that phloretin and siRNA silencing of GLUT1 decreased glucose uptake. However, unlike phloretin treatment, …
WebbThe natural polyphenol, phloretin, similar to WZB117, inhibits GLUT2 mRNA and protein expression by blocking hepatocyte nuclear factor 6 (HNF6). Phloretin alone or in … WebbWZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. CAS No. 1223397-11-2. Selleck's WZB117 has been cited by 10 Publications. Purity & Quality Control. Biological Activity ...
Webb1 apr. 1996 · In this reconstituted system, D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin …
WebbGlucose transporter 1 (GLUT1) serves as a ubiquitously expressed glucose transporter, which could activate inflammatory response by mediating glycolysis. Phloretin (PHL), an … chuck albert footlockerWebbGLUT activity was partially inhibited by cytochalasin B (IC (50) = 0.44 +/- 0.1; K (i) = 0.3 +/- 0.1 microM) and phloretin (IC (50) = 8.7 microM) in AS-30D hepatocarcinoma. At physiological glucose, GLUT1 and GLUT3 were the predominant active isoforms in HeLa cells and AS-30D cells, respectively. designer shoe shops in manchesterWebb17 okt. 2024 · After 30 min, they were intraperitoneally injected with 200 μl of 20 wt% glucose solution, followed by an intravenous injection of the GLUT1 inhibitor phloretin (10–50 mg/kg) 38 at 20 min after ... designer shoe shops in newcastleWebb6 juni 2012 · glucose and several recognized GLUT1 inhibitors: phloretin, forskolin, and cytochalasin B. Glucose, forskolin, and phloretin. docked at sites located in close mutual proximity on the. chuck albiWebbBackground: Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy. Glucose transporter-1 (GLUT1) facilitates the transport of glucose into VSMCs, and GLUT1 overexpression associated … designer shoes high topsWebbKL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50 s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. designer shoes for tall womenWebbPhloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively.Phloretin has the potential for the treatment of … chuck albrecht chicago